A1 - Whole-Body Soft-Tissue Lesion Tracking and Segmentation in Longitudinal CT Imaging Studies

Alessa Hering, Felix Peisen, Teresa Amaral, Sergios Gatidis, Thomas Eigentler, Ahmed Othman, Jan Hendrik Moltz

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In follow-up CT examinations of cancer patients, therapy success is evaluated by estimating the change in tumor size. This process is time-consuming and error-prone. We present a pipeline that automates the segmentation and measurement of matching lesions, given a point annotation in the baseline lesion. First, a region around the point annotation is extracted, in which a deep-learning-based segmentation of the lesion is performed. Afterward, a registration algorithm finds the corresponding image region in the follow-up scan and the convolutional neural network segments lesions inside this region. In the final step, the corresponding lesion is selected. We evaluate our pipeline on clinical follow-up data comprising 125 soft-tissue lesions from 43 patients with metastatic melanoma. Our pipeline succeeded for 96% of the baseline and 80% of the follow-up lesions, showing that we have laid the foundation for an efficient quantitative follow-up assessment in clinical routine.
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Wednesday 7th July
A1-3 (long): Segmentation - 13:00 - 13:30 (UTC+2)
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